FORMULATION OF RIFAMPICIN SUPPOSITORIES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 11, Volume 13, Issue 1, June 1990, Pages 97-102 PDF (238.4 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1990.70551 | ||
| Authors | ||
| H. Abdel-Monem Sayed; S. Ismail; A. A. Mohamed | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Rifampicin is a powerful bactericidal antitubercular drug. The drug was formulated as suppositories. Witepsol H12 was used as the formulating base. Certain other bases as witepsol H15 and W35 and Massa estarinum B and BC as well as cacao butter replaced witepsol H12. Non-ionic surfactants with different chemical compositions, different HLB values as well as different physical and solubility properties were incorporated into witepsol H12 at 5% concentration, of the tested surfactants were polysorbates. Spans, Myrjs and Brijs. Drug dialysis into saline solution at 37°C was studied through cellophane membrane, of the tested bases. Witepsols gave the highest dialysis rates. Polysorbates proved to be superior among the tested surfactants. | ||
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