SYNTHESIS OF NEW [1,5]-BENZODIAZEPINE DERIVATIVES CATALYZED BY VARIOUS ALIPHATIC ACIDS | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 8, Volume 48, Issue 2 - Serial Number 48, September 2013, Pages 114-119 PDF (348.97 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2013.7099 | ||
| Author | ||
| Kamal El-Gaml | ||
| Organic chemistry department, Al-Azher University, Naser city, Cairo, 11884, Egypt | ||
| Abstract | ||
| A series of some new[1,5]benzodiazepines has been synthesized using condensation reaction of o-phenelendiamine with different newly synthesized quinolinyl ketones and effect of different aliphatic acids used as a catalyst was studied. Among the catalytic screened aliphatic acid, chloroacetic acid are a versatile catalyst that modify the yield (60-95%) in short reaction time. | ||
| Keywords | ||
| 1; 5 – benzodiazepine; o-phenelendiamine; quinolinyl ketones; aliphatic acids | ||
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