Adolf Barsoom, S., Baghdadi, H., El-kammar, H., Afifi, N. (2019). Correlation between Inflammatory Signals and Tumor Associated Macrophages in Oral Squamous Cell Carcinoma. test, 65(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 241-252. doi: 10.21608/edj.2015.71408
Sarah Adolf Barsoom; Houry Moustafa Baghdadi; Hala A. El-kammar; Nermeen S Afifi. "Correlation between Inflammatory Signals and Tumor Associated Macrophages in Oral Squamous Cell Carcinoma". test, 65, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2019, 241-252. doi: 10.21608/edj.2015.71408
Adolf Barsoom, S., Baghdadi, H., El-kammar, H., Afifi, N. (2019). 'Correlation between Inflammatory Signals and Tumor Associated Macrophages in Oral Squamous Cell Carcinoma', test, 65(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 241-252. doi: 10.21608/edj.2015.71408
Adolf Barsoom, S., Baghdadi, H., El-kammar, H., Afifi, N. Correlation between Inflammatory Signals and Tumor Associated Macrophages in Oral Squamous Cell Carcinoma. test, 2019; 65(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 241-252. doi: 10.21608/edj.2015.71408

Correlation between Inflammatory Signals and Tumor Associated Macrophages in Oral Squamous Cell Carcinoma

Egyptian Dental Journal
Article 3, Volume 65, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), January 2019, Pages 241-252    PDF (2.25 M)
Document Type: Original Article
DOI: 10.21608/edj.2015.71408
Authors
Sarah Adolf Barsoom1; Houry Moustafa Baghdadi2; Hala A. El-kammar3; Nermeen S Afifi4
1Teaching Assistant of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt
2Professor and Head of Oral Pathology Department, Faculty of Dentistry, Ain Shams University
3Lecturer of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt.
4Lecturer of Oral Pathology, Faculty of Dentistry, Ain Shams University
Abstract
Background: Squamous cell carcinoma grows in a complex and dynamic stroma. This microenvironment provides all the necessary stimuli for tumor viability, growth and invasiveness. COX-2 is upregulated during both inflammation and cancer. CD163, a marker of M2 macrophages (Tumor associated macrophages- TAMs), has been studied in several aggressive tumors. The increased expression of CD163 was associated with a poor overall survival in various cancers.
Aims of the Study: The present study aimed to correlate the inflammatory signals presented by COX-2 immunoexpresion with tumor associated macrophages expressing CD163 in different grades of OSCC.
Materials and methods: Immunohistochemical expression of COX-2 and CD163 was evaluated in 30 cases of different grades of OSCC.
Results: The mean difference between the well-differentiated level and the moderately differentiated level of COX-2 and CD 163 was statistically insignificant, while that between the well- and poorly differentiated and between the moderately and the poorly differentiated were highly statistically significant.
Conclusions: inflammatory signals presented by COX-2 immunoexpression and TAM (CD163+ cells) were elevated with increased tumor grade.
Keywords
COX-2; Tumor associated macrophages; CD 163; Squamous cell carcinoma
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