Chemopreventive effect of capsaicin in experimentally induced hamster buccal pouch carcinogenesis (Immunohistochemical study Bcl-2) | ||
| Egyptian Dental Journal | ||
| Article 9, Volume 65, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2019, Pages 1237-1243 PDF (1.61 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2019.72201 | ||
| Authors | ||
| Mohamed Abdelrahman Mohamed1; Ali Abdullah AlQarni2 | ||
| 1Assistant Professor of Oral Pathology , Faculty of Dentistry , Al-Azhar University | ||
| 2Teaching Assistant of Oral Medicine , Faculty of Dentistry , Taif University | ||
| Abstract | ||
| Aim:To investigate immunohistochemically the effect of chemopreventive capsaicin in epithelial alteration (Epithelial dysplasia) & carcinogenesis which induced in hamsters. Methods: Hematoxylin and Eosin (H&E) and Streptavidin-biotin immunoperoxidase staining techniques was used to detect the expression of Bcl-2 in three groups (G1, G2 and G3). Evaluation of immunostaining was done using computer image analyzer system & statistical analysis. Results: showed that there was a statistically highly significant difference (P<0.01) in means values of all groups (G2>G1, G3) (G3>G1). Conclusion:Capsaicin play an important role in reduction and prevention of transformation of epithelial dysplasia into malignant tumor especially oral squamous cell carcinoma. The liquid form of capsaicin may be considered as a new line of treatment in oral dysplasia or even in oral squamous cell carcinoma and the Bcl-2 expression evidenced this reduction of abnormality in epithelial dysplasia. | ||
| Keywords | ||
| Oral Epithelial Dysplasia; chemopreventive effect; Capsaicin; Bcl-2; induced hamster carcinogenesis | ||
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