Mourad, S., Awad, S., Shamaa, A. (2019). Vascularity and angiogenesis level correlations with the clinical behavior of the central and peripheral giant cell granulomas of the oral cavity. test, 65(Issue 3 - July (Oral Surgery)), 2209-2218. doi: 10.21608/edj.2019.72247
Samah I. Mourad; Sally Awad; Ali Shamaa. "Vascularity and angiogenesis level correlations with the clinical behavior of the central and peripheral giant cell granulomas of the oral cavity". test, 65, Issue 3 - July (Oral Surgery), 2019, 2209-2218. doi: 10.21608/edj.2019.72247
Mourad, S., Awad, S., Shamaa, A. (2019). 'Vascularity and angiogenesis level correlations with the clinical behavior of the central and peripheral giant cell granulomas of the oral cavity', test, 65(Issue 3 - July (Oral Surgery)), pp. 2209-2218. doi: 10.21608/edj.2019.72247
Mourad, S., Awad, S., Shamaa, A. Vascularity and angiogenesis level correlations with the clinical behavior of the central and peripheral giant cell granulomas of the oral cavity. test, 2019; 65(Issue 3 - July (Oral Surgery)): 2209-2218. doi: 10.21608/edj.2019.72247

Vascularity and angiogenesis level correlations with the clinical behavior of the central and peripheral giant cell granulomas of the oral cavity

Egyptian Dental Journal
Article 16, Volume 65, Issue 3 - July (Oral Surgery), July 2019, Pages 2209-2218    PDF (2.5 M)
Document Type: Original Article
DOI: 10.21608/edj.2019.72247
Authors
Samah I. Mourad1; Sally Awad1; Ali Shamaa2
1Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
2Professor, Department of Oral Biology, Faculty of Dentistry, Minia University, Egypt.
Abstract
Purpose: The aim of the current study was to compare vascularity and angiogenic activity in peripheral and central giant cell granulomas (GCGs) of the jaws as reflected by vascular endothelial growth factor (VEGF). Patients and Method: 3 males and 7 females complaining of peripheral giant cell granuloma (PGCGs) and fifteen (5 males & ten females) with central giant cell granuloma (CGCGs) were selected to assess and compare the VEGF immunoexpression in multinucleated giantcells, and mononuclear surrounding stroma. Results: The expression levels of VEGF were greater in CGCGs compared to PGCGs and in aggressive CGCG more than non-aggressive. Conclusion: The vascularity and level of angiogenesis within aggressive CGCGs are higher than those in non-aggressive lesions. The stronger VEGF expression, the higher clinical behavior aggressiveness of the different giant cells granuloma lesions.
Keywords
Angiogenesis; Giant cell Granuloma; Oral; VEGF
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