Kamel, S., Younis, M., Morsy, R. (2019). Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study). test, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2241-2252. doi: 10.21608/edj.2019.72256
Samah Mohamed Kamel; Mohamed Abdel Salam El Baz Younis; Reham A.A. Morsy. "Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study)". test, 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2019, 2241-2252. doi: 10.21608/edj.2019.72256
Kamel, S., Younis, M., Morsy, R. (2019). 'Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study)', test, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2241-2252. doi: 10.21608/edj.2019.72256
Kamel, S., Younis, M., Morsy, R. Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study). test, 2019; 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2241-2252. doi: 10.21608/edj.2019.72256

Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study)

Egyptian Dental Journal
Article 2, Volume 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2019, Pages 2241-2252    PDF (3.11 M)
Document Type: Original Article
DOI: 10.21608/edj.2019.72256
Authors
Samah Mohamed Kamel1; Mohamed Abdel Salam El Baz Younis2; Reham A.A. Morsy3
1Lecturer, Department of Oral Biology, Faculty of Dentistry, October University of Modern Sciences and Art
2** Lecturer, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, October University of Modern Sciences and Art.
3Assoc Prof Basic Dental Science Department NRC
Abstract
Objectives: the aim of this study is to evaluate the healing and anti-inflammatory effects of propolis in critical wound defects in rats ‘ buccal mucosa.
Subjects& methods: 20 adult male albino rats of average weight 150-250 grams were used. Rats were divided into 2 groups
Group I: consists of 10 rats, which were subdivided into 2 sub groups
Sub Group I A: consists of 5 rats, the wounds were left un treated for 3 days
Sub Group I B: consists of 5 rats, the wounds were left un treated for 7 days
Group II: Consists of 10 rats which were subdivided into 2 sub groups
Sub Group II A: consists of 5 rats, the wounds were treated with propolis for 3 days
Sub Group II B: consists of 5 rats, the wounds were treated with propolis for 7 days
The wounds were examined histologically, histochemically and immunohistochemically
Results: Histologiacally, histochemical and immunohistochemical results showed that the healing process was faster in propolis treated rats due to anti inflammatory and anti oxidant effects of Propolis. Immunohistochemical labeling of vimentin in propolis treated groups was higher than un treated groups
Conclusion: Propolis could improve wound healing by stimulating the proliferation of epithelial cells; and fibroblast proliferation, thus improving wound closure and decreasing inflammation (as prolonged inflammation and the release of inflammatory cytokines could cause tissue damage)
Keywords
Wound healing; anti inflammatory; Propolis; vimentin
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