Soliman, A., Kamel, M., Eweas, A., Wietrzyk, J., Milczarek, M. (2018). The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells. test, 61(3), 423-429. doi: 10.21608/ejchem.2018.2934.1242
Abdel-Mohsen M. Soliman; Mohsen Kamel; Ahmed F. Eweas; Joanna Wietrzyk; Magdalena Milczarek. "The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells". test, 61, 3, 2018, 423-429. doi: 10.21608/ejchem.2018.2934.1242
Soliman, A., Kamel, M., Eweas, A., Wietrzyk, J., Milczarek, M. (2018). 'The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells', test, 61(3), pp. 423-429. doi: 10.21608/ejchem.2018.2934.1242
Soliman, A., Kamel, M., Eweas, A., Wietrzyk, J., Milczarek, M. The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells. test, 2018; 61(3): 423-429. doi: 10.21608/ejchem.2018.2934.1242

The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells

Egyptian Journal of Chemistry
Article 4, Volume 61, Issue 3, May and June 2018, Pages 423-429    PDF (568.9 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2018.2934.1242
Authors
Abdel-Mohsen M. Soliman* 1; Mohsen Kamel1; Ahmed F. Eweas1; Joanna Wietrzyk2; Magdalena Milczarek2
1Department of Therapeutic Chemistry National Research Centre, El-Buhouth St., P.O. 12622, Dokki, Giza, Egypt
2Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland
Abstract
Some new and known substituted 1,2,3,4-tetrahydroacridines incorporated at their position nine with various sulfa drug or thiosemicarbazide moieties were synthesized. Biologically, these compounds were investigated for their antiproliferative activity against human breast cancer (MCF-7) cell line compared to murine fibroblast normal cell line (BALB/3T3). The results were calculated as the IC50 (inhibitory concentration 50%) compared with Cisplatin as control. Furthermore, a docking simulation study was carried out to predict the inhibitory mode of action of the most active compounds.
Keywords
Antiproliferative activity; sulphonamides; MCF-7; BALB/3T3; Molecular docking
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