Zaiton, A., Assem, Y., Arafa, A., Momen, A., Said, S. (2018). Synthesis of Some Bioactive Compounds and its Application as Antimicrobial Agents for Plastic Industry. test, 61(3), 431-445. doi: 10.21608/ejchem.2018.2947.1243
Ahmed Zaiton; Yasser Assem; Amany Arafa; Ahmed Momen; Said Said. "Synthesis of Some Bioactive Compounds and its Application as Antimicrobial Agents for Plastic Industry". test, 61, 3, 2018, 431-445. doi: 10.21608/ejchem.2018.2947.1243
Zaiton, A., Assem, Y., Arafa, A., Momen, A., Said, S. (2018). 'Synthesis of Some Bioactive Compounds and its Application as Antimicrobial Agents for Plastic Industry', test, 61(3), pp. 431-445. doi: 10.21608/ejchem.2018.2947.1243
Zaiton, A., Assem, Y., Arafa, A., Momen, A., Said, S. Synthesis of Some Bioactive Compounds and its Application as Antimicrobial Agents for Plastic Industry. test, 2018; 61(3): 431-445. doi: 10.21608/ejchem.2018.2947.1243

Synthesis of Some Bioactive Compounds and its Application as Antimicrobial Agents for Plastic Industry

Egyptian Journal of Chemistry
Article 5, Volume 61, Issue 3, May and June 2018, Pages 431-445    PDF (1.05 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2018.2947.1243
Authors
Ahmed Zaiton1; Yasser Assem* 2; Amany Arafa3; Ahmed Momen4; Said Said4
1Research and development department, Egyptian company for plastic industry (Elsewedy-EgyPlast) 10th of Ramadan City, Egypt.
2Polymers and Pigments Department, National Research Centre
3Department of Microbiology and Immunology, National Research Centre
4Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
Abstract
New biocidal compounds were synthesized by reacting 4-hydroxy acetophenone with ethyl cyanoacetate and 2-chlorobenzaldehydes and ammonium acetate in absolute ethanol to give 4-(2-chlorophenyl)-2-hydroxy-6-(4-hydroxyphenyl) nicotinonitrile which by epoxidation gives 4-(2-chlorophenyl)-6-(4-(oxiran-2-ylmethoxy) phenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile. Another compound was synthesized by reacting 4-hydroxy acetophenone with ethyl cyanoacetate and 4-nitrobenzaldehydes and ammonium acetate in absolute ethanol to give 2-hydroxy-6-(4-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitrile witch by epoxidation gives 4-(4-nitrophenyl)-6-(4-(oxiran-2-ylmethoxy) phenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile. The synthesized four compounds and standard biocide (Zn omadine) were added separately to LDPE and HDPE and polystyrene in the same ratio (0.1 phr) followed by studying the melt flow rate and mechanical properties and electrical properties of LDPE and HDPE and polystyrene. In addition the biological activity of the prepared blends with LDPE or HDPE or PS were studied against two local isolates E. coli sero type O145 as gram-negative bacteria and S. epidermidis as gram-positive bacteria The antimicrobial test was performed quantitatively using the standard test method .
Keywords
2-pyridone; epoxidation; antimicrobial activity; Plastic; polyethylene; polystyrene
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