AVAILABILITY OF PHENYLEPHRINE HYDROCHLORIDE FROM OPHTHALMIC MULTIPLE EMULSIONS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 7, Volume 11, Issue 2, December 1988, Pages 248-260 PDF (419.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1988.73518 | ||
| Authors | ||
| A. A. Mohamed; S. Ismail; F. S. Habib; M. A. Attia | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Phenylephrine hydrochloride was formulated in different emulsion systems with and without viscolizers (methylcellulose and tylose). The diffusion coefficient of phenylephrine hydrochloride in different formulation has been determined. Results indicated that the diffusion coefficient of Phenylephrine hydrochloride from different systems decreased with increasing viscolizer concentration. The mydriatic and intraocular pressure, IOP, responses were followed after the application of the tested formulations to the rabbit's eye. Four parameters have been utilized to assess the performance of the drug formulations. These are the area under the curve AUC; the maximum response, MR; the time of maximum response. TMR; and the duration of drug action. DA. It was found that the most effective emulsion system appeared to be the multiple w/o/w emulsion containing 1% w/v methylcellulose followed by that containing 0.5% w/v tylose. | ||
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