Habib, F., Sayed, H., Ismail, S., Shaker, S., Shaker, A. (1987). FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES. test, 10(1), 123-145. doi: 10.21608/bfsa.1987.74050
F. S. Habib; H. A. Sayed; S. Ismail; S. Shaker; A. Shaker. "FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES". test, 10, 1, 1987, 123-145. doi: 10.21608/bfsa.1987.74050
Habib, F., Sayed, H., Ismail, S., Shaker, S., Shaker, A. (1987). 'FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES', test, 10(1), pp. 123-145. doi: 10.21608/bfsa.1987.74050
Habib, F., Sayed, H., Ismail, S., Shaker, S., Shaker, A. FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES. test, 1987; 10(1): 123-145. doi: 10.21608/bfsa.1987.74050

FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES

Bulletin of Pharmaceutical Sciences Assiut University
Article 8, Volume 10, Issue 1, June 1987, Pages 123-145    PDF (772.79 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1987.74050
Authors
F. S. Habib1; H. A. Sayed1; S. Ismail1; S. Shaker2; A. Shaker1
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Chlordiazepoxide hydrochloride (CDZ); is formulated in different suppository bases. Its in vitro release from these selected suppository bases was studied and found to be base dependent. The effect of drug concentration was also studied. The percentage of drug diffused, through cellophane membrane, increased with decreasing the drug concentration. Drug particle size was found to have an insignificant effect on the release rate.
Histological studies of the rabbit rectal mucosa after the rectal insertion of the tested suppository bases either alone or in the presence of CDZ showed insignificant histological changes.
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