Blood eosinophils and its relation to sputum inflammation and sputum bacterial load in patients with acute exacerbation of chronic obstructive pulmonary disease | ||
| Journal of Recent Advances in Medicine | ||
| Article 9, Volume 1, Issue 2, July 2020, Pages 116-127 PDF (1.23 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jram.2020.23857.1038 | ||
| Authors | ||
| Fatma Elsayed* 1; Magd Galal2; Manal Refaat Hafez2; Asmaa Elmadbouly3 | ||
| 1Ashmoun Chest Hospital, Menoufia, Egypt | ||
| 2Chest Diseases Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||
| 3Clinical Pathology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||
| Abstract | ||
| Background: little is recognized on the role eosinophils in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Objective: To assess the relationship between eiosinophilic AECOPD and sputum inflammation and bacterial load. Methodology: A cross-sectional study was done on 80 out of 189 patients presented by clinical picture of AECOPD. Spirometry, total and differential leucocytic count (TLC), sputum bacterial load and culture were done for all participants. They were divided into two subgroups based on blood eosinophils %; eosinophil high AECOPD (≥2%) and eosinophil low AECOPD (˂ 2%). Results: Among the studied patients; 51.25% have eosinophilhigh and 48.75% have eosinophil low AECOPD. Patients with eosinophils high AECOPD had higher age, BMI, smoking status, smoking index, wheezes and FVC%, with more severe COPD and more severe AECOPD (p0.018) than those with eosinophil low AECOPD. In patients with eosinophil high AECOPD the blood TLC/cm3 and neutrophil % were significantly lower, while lymphocyte % and eosinophil /cmm3 were higher significantly than eosinophil low AECOPD (p 0.001 each). Regarding sputum inflammatory cells they had significant increase of sputum lymphocyte % and eosinophil/cm3 and % with significant decrease of sputum neutrophils % (p˂0.05). In eosinophil high AECOPD subgroup the blood eosinophil /cmm3 was positively correlated with age, BMI and smoking index, blood lymphocytes % eosinophils %, sputum lymphocytes % and sputum eosinophils and it was negatively correlated with blood TLC, blood and sputum neutrophils, FEV1/FVC ratio, FEV1 % FEF25-75 % and FVC%. The sputum bacterial load was non-significantly lower in eosinophil high than eosinophil low AECOPD (61.0% vs. 74.4%, p=0.20).The type of the isolated bacteria didn’t differ between both AECOPD subgroups (p=0.17). Conclusion: Eosinophilic AECOPD is common and it was related to airway inflammation and it didn’t’ affect sputum bacterial load or type of isolated bacterial species | ||
| Keywords | ||
| Airway inflammation; eosinophilic AECOPD; sputum eosinophilia; sputum bacterial load | ||
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