Cellular Mechanism involved in cypermethrin induced neurotoxicity | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Article 5, Volume 4, Issue 1, March 2020, Pages 32-39 PDF (493.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/rpbs.2019.17969.1043 | ||
| Author | ||
| Hafiz Farhat Ali* | ||
| Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia , Egypt | ||
| Abstract | ||
| Cypermethrin (CYP): Is a class II synthetic pyrethroid that can cause in general irritation, itching at skin and eyes, burning sensation and loss of bladder control through ingestion or directly through dermal absorption exerts. It causes neurotoxicity passing through blood brain barrier in the central nervous system & induces motor deficits. Cypermethrin does not only causing neurotoxicity on central nervous system, but it's also affecting the peripheral nervous system.The inhibtory effect on the γ-aminobutyric acid (GABA) receptor, causing excitability and convulsions by decreasing the calcium uptake by nerves, suppression in immune system function in rats, it showed decrease in the numbers of Natural killer NK cells and increase in serum immunoglobulins (Igs) and causes early embryonic deaths, damage in genetic material, disrupts the sexual behavior and estrous cycle disruption. Exposure to low dose of CYP didn’t produce any alternation in GPx, CAT, and SOD activities. Generates proinflammatory cytokines as interleukins (IL) and tumor necrosis factor alpha (TNF-α) induced by activation of microglia and astrocytes caused by cypermethrin, this activation led to increase the level of TNF-α and IL-1β. | ||
| Keywords | ||
| cypermethrin; GABA; GPx; TNF-α; IL-1β | ||
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