ADSORPTION OF ROTOXAMINE TARTRATE BY AVICEL pH 101 | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 2, Volume 9, Issue 1, June 1986, Pages 11-24 PDF (357.65 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1986.74470 | ||
| Authors | ||
| Sayed Ismail; Sohair El-Shanawany | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut Egypt | ||
| Abstract | ||
| The adsorption of rotoxamine tartrate (RT) by avicel pH 101 was studied at a variety of pH values and in the presence of different concentrations of sodium lauryl sulfate (SLS), sodium cholate (SC), PVP 44000 and different electrolytic species. The results obtained were well described by the Langmuir equation. The limiting adsorptive capacity and the affinity constant were calculated. The data revealed that as the pH value was increased the limiting adsorptive capacity (a value) decreased. The results also revealed that as the concentration of SLS or SC was increased the affinity of the drug to be adsorbed was decreased. The adsorption of RT was found to be dependent on the type of the electrolyte used. It was found that the degree of adsorption decreased as the valence of the basic radicle of the elyctrolyte increased. PVP was found to have a suppression effect on the amount of RT adsorbed by avicel. Interpretation of the results obtained is also offered. | ||
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