FORMULATION AND EVALUATION OF TRIMETHOPRIM-SULFAMETHOXAZOLE SUPPOSITORIES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 3, Volume 9, Issue 1, June 1986, Pages 25-39 PDF (449.27 K) | ||
| DOI: 10.21608/bfsa.1986.74471 | ||
| Authors | ||
| A. H. Abd El-Gawad; E. Ramadan; A. T. Nouh | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Suppositories containing a mixture of trimethoprim (80 mg) and sulfamethoxazole (400 mg) per each were prepared using the fusion method. Witepsol H15 with and without 10% Tween 60 as the mixture of PEG 6000, 4000, 1540 (47:33:20) were used as suppository bases. The physice-chemical properties, in-vitro and in-vivo availability were investigated. The amount of drug released showed that Witepsol H15 with 10% Tween 60 gave the highest amount of SMZ and TMP released. Meanwhile, no much difference has been found in case of suppositories made with Witepsol H15 and the mixture of PEG bases. This indicated that the incorporation of Tween 60 in 10% concentration has a great role in enhancing the release properties of both drugs. The bioavailability study has proved the same findings of the in-vitro investigations, as it was found that Witepsol H15 incorporated with surfactant was the most suitable base for the preparation of TMP-SMZ suppositories. | ||
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