DISSOLUTION BEHAVIOUR OF TOLAZAMIDE IN THE PRESENCE OF CERTAIN NON-IONIC SURFACTANTS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 5, Volume 9, Issue 1, June 1986, Pages 60-70 PDF (324.91 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1986.74475 | ||
| Authors | ||
| Sayed Ismail; Ali A. Abdel Rahman | ||
| Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| The dissolution rate of tolazamide, on oral hypoglycemic drug, was studied in distilled water as well as solutions of polysorbates and myrjs at 30°C using the beaker method. The surfactant concentration was increased from 0.001 to 0.5% W/V in order to study the effect of the surfactant concentration on the dissolution rate of tolazamide. The relative area under the curve, from0-60 minutes (R.A.U.C.0-60) was used as a parameter to compare the effect of different surfactants, used at the same concentration (0.5% W/V), on the dissolution rate of tolazamide. It was found that the amount of the drug dissolved was significantly dependent on the concentration of each surfactant used as well as the type of the surfactant. The mechanism of the increase in the dissolution rate was also discussed. | ||
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