UTILITY OF XANTHYDROL FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN PHARMACEUTICAL PHENOLS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 1, Volume 9, Issue 2, December 1986, Pages 1-13 PDF (298.52 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1986.74483 | ||
| Author | ||
| Michael E. El-Kommos | ||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| The reaction of xanthydrol with phenols was applied for the determination of thymol, guaiacol, morin and naringenin, out of 30 phenolic compounds tested. Mixture of methanolic solutions of the phenol and xanthydrol was heated in presence of hydrochloric acid for 10 minutes on a water bath. The lmax of the coloured chromogen was located in the vicinity of 485 nm (orange) to 540 nm (violet). Molar absorptivities range from 1.0x103 to 4.3x103. A linear correlation was found between absorbance at lmax and concentration in the range of 5-40 mcg ml-1 (for thymol), 20-100 mcg ml-1 (for guaiacol) and 20-150 mcg ml-1 (for morin and naringenin). | ||
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