The Potential Impacts of Gold Nanoparticles on the Mucous Membrane of the Albino Rats' Tongues | ||
| Dental Science Updates | ||
| Article 7, Volume 1, Issue 1, March 2020, Pages 63-73 PDF (1.72 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/dsu.2020.16899.1011 | ||
| Authors | ||
| Mai Osman El-Halwagy* 1; Laila Sadek Ghali2; Mervat Mohamed Youssef3; Enas Mahmoud Hegazy4 | ||
| 1Oral Biology Department, Faculty of Dentistry, Sinai University, Ismaillia, Egypt | ||
| 2Professor Oral Biology, Faculty of Oral and Dental Medicine, Cairo University Dean of Faculty of Dentistry, Sinai University, Kantara branch, Egypt | ||
| 3Head of Department of Oral Biology, Faculty of Dentistry, Suez Canal University | ||
| 4Department of Oral Biology, Faculty of Dentistry, Suez Canal University | ||
| Abstract | ||
| Abstract Introduction: With the growing interest in the applications of gold nanoparticles (AuNPs) in biotechnology and their physiological effects, possible toxicity of gold nanoparticles is becoming an increasingly important issue. It was shown that the toxicity is both dose- and size-dependent, and the AuNPs of higher concentration would cause more cytotoxicity. Objectives: The aim of this work was to study the toxic effect of intraperitoneal administration of gold nanoparticles -if any- on the mucous membrane of the tongues of albino rats and the possibility of one-month recovery period. Material and methods: Forty-six male albino rats were used in the present investigation. They were divided into the following groups: Group (1) (16 rats) served as controls, they received the solvent of AuNPs intraperitoneally daily for 21 days. Group (2) (15 rats) received 10mg/kg body weight of AuNP solution intraperitoneally daily for 21 days. Group (3) (15 rats) were treated the same way as Group 2 for 21 days and then left for one-month as a recovery period. Results: Examination of the tongue of the rats which were exposed to gold nanoparticles solution revealed atrophic and degenerative changes of both the dorsal and ventral surfaces of the tongue as well as the lingual salivary glands. The examined tongues of the rats which were allowed a recovery period showed improvement in the histological picture. Conclusion: Exposure to over dose of AuNPs causes atrophic and degenerative changes. A recovery period of one-month can lead to regeneration and improvement in the histological picture. | ||
| Keywords | ||
| Gold nanoparticles; Biodistribution; Histological examination; Reactive oxygen species; tongue papillae; toxicity | ||
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