Assessment of cardiotoxicity in survivors of Acute Lymphoblastic Leukemia by Tissue Doppler imaging | ||
| Zagazig University Medical Journal | ||
| Article 18, Volume 28, Issue 3, May 2022, Pages 526-533 PDF (508.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2020.22066.1677 | ||
| Authors | ||
| nesma altantawy* 1; laila metwaly sherief2; AL Shaymaa Ahmed Ahmed Ali3; Osama AbdelAziz Gaber4 | ||
| 1pediatric department Mit Ghamr hospital Dakahleia governrate Egypt | ||
| 21.Pediatric Hematology and Oncology –Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||
| 3Department of Pediatrics Faculty of Medicine – Zagazig University, Egypt | ||
| 4Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| Abstract | ||
| ABSTRACT Background: Cardiotoxicity development in survivors of acute lymphoblastic leukemia is one of the most serious chronic complications of cancer therapy. Objectives: This study aimed to assess the frequency of doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia. Methods: We utilized a cross section case-control study design and included 50 ALL survivors attending pediatric oncology clinic for follow up after finishing chemotherapy and 50 age- and sex-matched controls. All participants were subjected to full general examination. The cardiac status was assessed by Echocardiography and Tissue Doppler Technique.Results:. Tissue doppler parameters S" (myocardial systolic velocity) m/sec, E" (early phase of diastole negative velocity) and A” m/sec (late phase of diastole negative velocity) , A (peak early mitral inflow velocity) and E (peak late mitral inflow velocity) wave DT(deceleration time) ,GCS(global circumferential strain) &GLS(global longtudinal strain) were statistically lower among ALL survivor, than controls,but MPI(myocardial performance index) was statistically higher among ALL survivor than controls. Conclusion: Our results demonstrated that all echocardiographic and Tissue Doppler parameters are lower among ALL survivors than controls, except that MPI(myocardial performance index) , LVED (left ventricular end diastolic dimention) and LVES(left ventricular end systolic dimention) is higher among ALL survivors than controls indicating cardiac dysfunction among ALL survivors. | ||
| Keywords | ||
| Doxorubicin; ALL survivors; cardiotoxicity | ||
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