Abou-Zeid, A., Nassar, E., Swelem, M., Tawfik, M. (2018). Zinc-alpha 2-glycoprotein serum level in Egyptian females with preeclampsia and eclampsia. test, 8(2), 145-155. doi: 10.21608/ebwhj.2018.7510
Abla A. Abou-Zeid; Eman Saad Nassar; Manal Shafik Swelem; Marian Edwar Tawfik. "Zinc-alpha 2-glycoprotein serum level in Egyptian females with preeclampsia and eclampsia". test, 8, 2, 2018, 145-155. doi: 10.21608/ebwhj.2018.7510
Abou-Zeid, A., Nassar, E., Swelem, M., Tawfik, M. (2018). 'Zinc-alpha 2-glycoprotein serum level in Egyptian females with preeclampsia and eclampsia', test, 8(2), pp. 145-155. doi: 10.21608/ebwhj.2018.7510
Abou-Zeid, A., Nassar, E., Swelem, M., Tawfik, M. Zinc-alpha 2-glycoprotein serum level in Egyptian females with preeclampsia and eclampsia. test, 2018; 8(2): 145-155. doi: 10.21608/ebwhj.2018.7510

Zinc-alpha 2-glycoprotein serum level in Egyptian females with preeclampsia and eclampsia

Evidence Based Women's Health Journal
Article 1, Volume 8, Issue 2, May 2018, Pages 145-155    PDF (687.83 K)
Document Type: Original Article
DOI: 10.21608/ebwhj.2018.7510
Authors
Abla A. Abou-Zeid1; Eman Saad Nassar2; Manal Shafik Swelem3; Marian Edwar Tawfik* 4
1Clinical and Chemical Pathology, Faculty of Medicine, AlexandriaUniversity, Egypt
2Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt
3Obstetrics and Gynecology Department, Faculty of Medicine, AlexandriaUniversity, Egypt
4Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt
Abstract
Objective: The aim of this study was to measure serum zinc-α2-glycoprotein (ZAG) in pregnant Egyptian females with preeclampsia and eclampsia and to correlate its levels to biochemical measures of kidney function, lipid and glucose metabolism.
Study Design: It was a retrospective study.
Patients and Methods: This study measured ZAG levels by enzyme linked immunosorbent assay (ELISA) in pregnant females with preeclampsia (PE) (no. = 40) and eclampsia (no.=20) and were compared to healthy gestational age-matched subjects (no.=20). In addition, the association of ZAG with kidney function, lipid and glucose metabolism was studied.
Results: Significant difference was detected on comparing the different groups regarding ZAG levels (p = 0.001). Furthermore, ZAG was positively correlated to systolic blood pressure, urinary protein, fasting insulin and HOMA-IR.After adjusting for other parameters,the association between ZAG and SBP, urinary protein, serum insulin and HOMA-IR remained significant by multivariate linear regression analysis.
Conclusion: The study noted that maternal ZAG serum levels are significantly increased in PE
Keywords
Adipokines; Eclampsia; preeclampsia; ZAG
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