FACTORS CONTROLLING MEASUREMENT OF THE CRUSHING STRENGTH OF CALCIUM SULFATE GRANULES EVALUATED BY BALL MILL | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 5, Volume 8, Issue 1, June 1985, Pages 61-79 PDF (493.22 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1985.75708 | ||
| Authors | ||
| Hamdy M. Abdel-Alim; Mohamed H. El-Shaboury | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Calcium sulfate dihydrate granules were prepared using (10%) aqueous PVP solution. The crushing strength of the prepared granules was evaluated according to the method adopted by Mehta et. al. using a ball mill. Many controlling factors such as the proportion of the feed, granule size (1875, 1025, 558 m), speed of rotation (low; I, moderate; II and high; III), type of balls (small porcelain, mixed porcelain and glass balls) and number of balls on the linearity of the equation were studied. The results obtained revealed that, the linearity of the equation was obvious as the proportion of the granules was increased. Granules of small size (1025 and 558 m ) gave under-estimation results. Upon increasing the time of milling, the linearity of the equation was obeyed. This finding was also achieved at law speed and on decreasing the number of balls. On the other hand, the linearity was obtained on decreasing the time of milling using glass and mixed balls as grinding media. In addition the time of milling was decreased at high speed. | ||
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