Ismaiel, S., Haney, Jr., W., Abdel-Moety, E. (1985). SPECTRODENSITOMETRIC DETERMINATION OF NICOTINAMIDE IN SOME MULTIVITAMIN PREPARATIONS. test, 8(2), 1-11. doi: 10.21608/bfsa.1985.75891
S. A. Ismaiel; W. G. Haney, Jr.; E. M. Abdel-Moety. "SPECTRODENSITOMETRIC DETERMINATION OF NICOTINAMIDE IN SOME MULTIVITAMIN PREPARATIONS". test, 8, 2, 1985, 1-11. doi: 10.21608/bfsa.1985.75891
Ismaiel, S., Haney, Jr., W., Abdel-Moety, E. (1985). 'SPECTRODENSITOMETRIC DETERMINATION OF NICOTINAMIDE IN SOME MULTIVITAMIN PREPARATIONS', test, 8(2), pp. 1-11. doi: 10.21608/bfsa.1985.75891
Ismaiel, S., Haney, Jr., W., Abdel-Moety, E. SPECTRODENSITOMETRIC DETERMINATION OF NICOTINAMIDE IN SOME MULTIVITAMIN PREPARATIONS. test, 1985; 8(2): 1-11. doi: 10.21608/bfsa.1985.75891

SPECTRODENSITOMETRIC DETERMINATION OF NICOTINAMIDE IN SOME MULTIVITAMIN PREPARATIONS

Bulletin of Pharmaceutical Sciences Assiut University
Article 1, Volume 8, Issue 2, December 1985, Pages 1-11    PDF (273.59 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1985.75891
Authors
S. A. Ismaiel1; W. G. Haney, Jr.2; E. M. Abdel-Moety3
1Research Directorate Misr Company for Pharmaceutical Industries, El-Mataria, Cairo, Egypt
2School of Pharmacy, University of Missouri, Kansas-City, Rockhill Road, Kansas City, Missouri 64110, U.S.A.
3Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr EI-Aini, Cairo, Egypt
Abstract
A sensitive, highly selective and stability indicating procedure for the determination of nicotinamide in some multi-vitamin preparations is described. The procedure is based on thin-layer chromatographic separation of nicotinamide from other constituents of the dosage form, the reaction with aniline and cyanogen bromide vapours, and spectrodensitometric determination at 468 nm. The method is suitable for content uniformity studies.
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