PREPARATION AND EVALUATION OF DIRECTLY COMPRESSED MEDAZEPAM HYDROCHLORIDE TABLETS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 7, Volume 8, Issue 2, December 1985, Pages 104-119 PDF (469.25 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1985.75898 | ||
| Authors | ||
| A. E. Aboutaleb; Aly A. Abdel Rahman; S. I. Saleh; M. O. Ahmed | ||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Medazepam, the well known benzodiazepine derivative used as a tranquilizer and in alcohol withdrawal, was prepared in directly compressed tablets. The directly compressible vehicles which were used singly or in binary blends 1:1, were Avicel, Lactose, STA-Rx 1500, Emcompress and the recently introduced vehicle, Compactrol. It was found that Avicel and Emcompress represent the most suitable efficient single vehicles used for the preparation of Medazepam hydrochloride tablets. In case of binary blends it was found that the best quality batches were prepared using Avicel : Emcompress blend 1:1. Physical characteristics including uniformity of weight, thickness, hardness, friability were investigated for the prepared batches. The effect of directly compressible vehicle variation on the uniformity of drug content and the dissolution rates of Medazepam hydrochloride tablets was also studied. | ||
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