FORMULATION OF INFANTILE EPHEDRINE HYDROCHLORIDE SUPPOSITORIES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 10, Volume 8, Issue 2, December 1985, Pages 143-157 PDF (489 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1985.75901 | ||
| Authors | ||
| A. H. Abd-El Gawad; A. T. Nouh; M. El-Shaboury | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Ephedrine hydrochloride suppositories were prepared with non-ionic surfactants, and using Witepsol H15, Witepsol W35 and Witepsol E75. Mixtures of H15 + W35 and H15 + E75 in 1:1 ratio were also used. The prepared suppositories were evaluated for physical properties and release characteristics and were found to be base and surfactant dependant. Amount of drug released from the base mixture was found to be higher than those obtained with the individual base. Addition of non-ionic surfactants variably affects the amount of drug released depending on the nature and concentration of the surfactant used. Brij 72 and Myrj 45 were found to decrease the amount of drug released, however Tween 80 increased the release rate. The surfactant composition was found to affect the drug release. In conclusion, it was found that formulation of ephedrine hydrochloride in suppository form, suitable for infantile administration was possible. | ||
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