Ghalwash, D., Mahmoud, E., Shaker, O. (2017). Evaluation of the therapeutic effect of topical calcipotriol versus topical tretinoin in treatment of oral Leukoplakia and their effect on clinical improvement and salivary level of MMP-9, IL-6 and TGF-β: A Randomized Clinical Trial. test, 63(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2441-2457. doi: 10.21608/edj.2017.76061
Dalia M. Ghalwash; Enji A. Mahmoud; Olfat G. Shaker. "Evaluation of the therapeutic effect of topical calcipotriol versus topical tretinoin in treatment of oral Leukoplakia and their effect on clinical improvement and salivary level of MMP-9, IL-6 and TGF-β: A Randomized Clinical Trial". test, 63, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2017, 2441-2457. doi: 10.21608/edj.2017.76061
Ghalwash, D., Mahmoud, E., Shaker, O. (2017). 'Evaluation of the therapeutic effect of topical calcipotriol versus topical tretinoin in treatment of oral Leukoplakia and their effect on clinical improvement and salivary level of MMP-9, IL-6 and TGF-β: A Randomized Clinical Trial', test, 63(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2441-2457. doi: 10.21608/edj.2017.76061
Ghalwash, D., Mahmoud, E., Shaker, O. Evaluation of the therapeutic effect of topical calcipotriol versus topical tretinoin in treatment of oral Leukoplakia and their effect on clinical improvement and salivary level of MMP-9, IL-6 and TGF-β: A Randomized Clinical Trial. test, 2017; 63(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2441-2457. doi: 10.21608/edj.2017.76061

Evaluation of the therapeutic effect of topical calcipotriol versus topical tretinoin in treatment of oral Leukoplakia and their effect on clinical improvement and salivary level of MMP-9, IL-6 and TGF-β: A Randomized Clinical Trial

Egyptian Dental Journal
Article 17, Volume 63, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2017, Pages 2441-2457    PDF (967.82 K)
Document Type: Original Article
DOI: 10.21608/edj.2017.76061
Authors
Dalia M. Ghalwash1; Enji A. Mahmoud2; Olfat G. Shaker3
1Associate Professor of Oral Medicine and Periodontology, Faculty of Dentistry. The British University in Egypt
2Associate Professor of Oral Medicine and Periodontology, Faculty of Dentistry. Cairo University
3Professor of Biochemistry, Faculty of Medicine. Cairo University
Abstract
Background: Leukoplakia is the most common potentially malignant lesion of the oral cavity. The main objective in treatment of oral leukoplakia is to prevent malignant transformation. Retinoids and vitamin D analogues have anti-keratinizing and immunomodulatory properties and proven effectiveness in the treatment of leukoplakia.
Aim of the study: the aim of this clinical trial was to compare the effectiveness of topical calcipotriol versus topical tretinoin in treatment of oral leukoplakia regarding changes in clinical score as well as salivary IL-6, TGF- β and MMP-9 levels.
Methodology: 40 patients with oral leukoplakia were randomly assigned into two groups. Group 1: (n=20) patients were treated with topical calcipotriol gel applied twice daily for 4 weeks. Group 2: (n=20) patients were treated with topical tretinoin cream applied twice daily for 4 weeks. Clinical improvement as well as salivary level of TGF-β, IL-6 and MMP-9 was evaluated 4 weeks after treatment and compared to baseline values.
Results: Both treatments resulted in clinical improvement with no significant differences between groups. However, calcipotriol produced a highly statistically significant reduction in salivary IL-6 and MMP-9 compared to tretinoin while both treatments caused significant reduction in salivary TGF-β with no significant difference.
Conclusion: Calcipotriol could be considered a promising therapeutic alternative with fewer side effects for the treatment of oral leukoplakia.
Keywords
Leukoplakia; Calcipotriol; Tretinoin; MMP-9; IL-6; TGF-β
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