Abou ElKhier, M., Amin, L., Salama, N. (2018). The role of Platelet Rich Fibrin in bone defect regeneration. test, 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1161-1170. doi: 10.21608/edj.2018.77001
Mazen T Abou ElKhier; Laila E Amin; Nagla M Salama. "The role of Platelet Rich Fibrin in bone defect regeneration". test, 64, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2018, 1161-1170. doi: 10.21608/edj.2018.77001
Abou ElKhier, M., Amin, L., Salama, N. (2018). 'The role of Platelet Rich Fibrin in bone defect regeneration', test, 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1161-1170. doi: 10.21608/edj.2018.77001
Abou ElKhier, M., Amin, L., Salama, N. The role of Platelet Rich Fibrin in bone defect regeneration. test, 2018; 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1161-1170. doi: 10.21608/edj.2018.77001

The role of Platelet Rich Fibrin in bone defect regeneration

Egyptian Dental Journal
Article 3, Volume 64, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2018, Pages 1161-1170    PDF (2.31 M)
Document Type: Original Article
DOI: 10.21608/edj.2018.77001
Authors
Mazen T Abou ElKhier1; Laila E Amin2; Nagla M Salama3
1Associate Professor of Oral Biology Department, Faculty of Dentistry, Mansoura University
2Lecturer of Oral Biology Department, Faculty of Dentistry, Mansoura University
3Associate professor of Oral Pathology Department, Faculty of Dentistry, Mansoura University
Abstract
Background: Natural tissue regeneration relies on a cocktail of signaling molecules and growth factors. During natural wound healing, activated platelets concentrate in the wound area and secrete factors that play a role in wound healing. Platelet rich fibrin (PRF) represents a revolutionary step in the platelet gel therapeutic concept. It needs only centrifugation of the natural blood without additives.
Objectives: This present study designed to evaluate the role of PRF on regeneration of bone defect.
Design: In this study 24New Zealand white male rabbits were used with bilateral cortical bony defects in the submental mandibular area, divided into two groups. The right bone defects were filled with PRF (experimental) and the left bone defects kept empty (control). Each group was equally subdivided into three subgroups; rabbits were sacrificed at 2nd, 4th and 6th weeks. Immunohistochemical analysis for collagen I and vascular endothelial growth factor (VEGF) were done.
Results: The histological findings illustrated that all experimental subgroups showed more deposition of osteoid tissue and well organized bone trabeculae. Immunohistochemical findings of collagen I revealed statistically to be the highest in PRF group. While VEGF illustrated a positive expression by bone marrow stromal cells and bone tissue cells in different value and the PRF group recorded the highest value.
Conclusion: It was concluded that PRF can accelerate bone regeneration and had effect on collagen I and VEGF expression.
Keywords
Bone defect; Platelet rich fibrin; Collagen I; VEGF
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