Shoman, A., Badwy, A., Elhammady, M., Eldesoki, Y. (2020). Effect of Proton Pump Inhibitors, Vitamin E and their co- administration on heart function and Oxidative Changes in Isoprenaline Induced Myocardial Infarction in Adult Male Albino Rats. test, 37(1), 169-183. doi: 10.21608/bmfj.2020.77404
Abeer Ahmed Shoman; Ahmed Badwy; Mohamed Elhammady; Yara Eldesoki. "Effect of Proton Pump Inhibitors, Vitamin E and their co- administration on heart function and Oxidative Changes in Isoprenaline Induced Myocardial Infarction in Adult Male Albino Rats". test, 37, 1, 2020, 169-183. doi: 10.21608/bmfj.2020.77404
Shoman, A., Badwy, A., Elhammady, M., Eldesoki, Y. (2020). 'Effect of Proton Pump Inhibitors, Vitamin E and their co- administration on heart function and Oxidative Changes in Isoprenaline Induced Myocardial Infarction in Adult Male Albino Rats', test, 37(1), pp. 169-183. doi: 10.21608/bmfj.2020.77404
Shoman, A., Badwy, A., Elhammady, M., Eldesoki, Y. Effect of Proton Pump Inhibitors, Vitamin E and their co- administration on heart function and Oxidative Changes in Isoprenaline Induced Myocardial Infarction in Adult Male Albino Rats. test, 2020; 37(1): 169-183. doi: 10.21608/bmfj.2020.77404

Effect of Proton Pump Inhibitors, Vitamin E and their co- administration on heart function and Oxidative Changes in Isoprenaline Induced Myocardial Infarction in Adult Male Albino Rats

Benha Medical Journal
Article 3, Volume 37, Issue 1, May 2020, Pages 169-183    PDF (1.25 M)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.77404
Authors
Abeer Ahmed Shoman* 1; Ahmed Badwy2; Mohamed Elhammady3; Yara Eldesoki4
1department of physiology, faculty of medicine, Benha university
2department of physiology 6th October Univerisity, Egypt.
3Department of physiology, Benha faculty of medicine, Benha University, Egypt
4department of physiology 6th October Univerisity, Egypt
Abstract
Background: Myocardial infarction (MI) continues to be associated with high morbidity and mortality worldwide. Proton Pump inhibitors (PPIs) exhibit cardioprotective effects by several mechanisms. Vitamin E possesses antioxidant properties. Aim: The present study has been designed to evaluate the combined cardioprotective effect of PPIs and vitamin E on biochemical and histopathological alteration in isoprenaline (ISO) induced myocardial infarction in rats. Methods: 30 adult Wistar albino male rats divided into 5 groups as follow: Group I: Control fed a standard diet.Group II: rats were undergoing MI by ISO. Group III: Rats were pretreated pantoprazole (1.3 mg/kg, i.o) daily for 3 weeks. Group IV: Rats were pretreated with vitamin E (100 IU/kg i.o) daily for 3 weeks. Group V: Rats were given both pantoprazole (1.3 mg/kg, i.o) and vitamin E (100 IU/kg bw, i.p) daily. On 22thand 23th day, rats in groups (II-V) were injection i.p with ISO (100mg/kg bw for successive two days). Results: ISO induced infarction in rats resulted in a significant elevation in ST segment height, T – wave voltage, Heart rate (HR), serum lactate dehydrogenase (LDH), malondialdehyde (MDA) and nitric oxide metabolites (NO), whereas it caused a significant (P < 0.05) decrease in systolic blood pressure(SBP) and serum superoxide dismutase (SOD) when compared with the control group. Moreover, interventions with PPIs supplementation and/or vitamin E significantly reversed the aforementioned parameters with better impact of their combination. Conclusion: PPIs combined with vitamin E exert potential protective effect against MI through lowering calcium overload and enhancement of antioxidant activity.
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