BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 24, Volume 47, Issue 2, August 2017, Pages 443-458 PDF (1.76 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2017.77951 | ||
| Authors | ||
| AMANY EL SAYED SABER1; ABDELWAHAB KHALIL ABDELWAHAB2; AZZA MOHAMED EL AMIR3; MAMDOUH IBRAHIM NASSAR4; HUSSEIN FOUAD ZOHDI1 | ||
| 1Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. | ||
| 2Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. | ||
| 3Department of Zoology, Faculty of Science, Cairo University,Giza, Egypt. | ||
| 4Department of Entomology, Faculty of Science, Cairo University, Giza, Egypt. | ||
| Abstract | ||
| Entamoeba histolytica is an invasive parasite and results in intestinal inflammation and amebic liver abscess. Metronidazole is the main used drug for amoebiasis in both adults and children. However, metronidazole has some drawbacks such as having potential mutagenic effects in rats as well as the problem of the emergence of drug- resistance species makes the development of other safer drugs for amoebiasis is critical. In this study we assessed the ability of bee venom (BV) loaded chitosan (CS) nanoparticles to treat amoebiasis and that BV has antiamoebic effect as well as it is proved that orally administered BV loaded CS nanoparticles can be a more effective alternative drug for amoebiasis than subcutaneously injected BV. | ||
| Keywords | ||
| Amoebiasis; Bee venom; Chitosan nanoparticles | ||
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