Evaluation of Periodontal Tissue Response to Non-Surgical Periodontal Therapy in Patients Work in Basic Chemical Industries and Ferti lizers Factory | ||
| Egyptian Dental Journal | ||
| Article 5, Volume 64, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2018, Pages 3313-3323 PDF (737.39 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2018.78886 | ||
| Authors | ||
| Hamdy AbdelMotagaly Metwaly1; Mohamed Abdel-Moniem Ebrahem2; , Hamdy Abdel Motagaly Metwaly3; Fatma Fathi Hussein4; Ahmed Abdallah Khalil4 | ||
| 1Assistant Professor, Department of Oral Pathology, Faculty of Dentistry, Tanta University | ||
| 2Professor, Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Minia University, Egypt | ||
| 3Assistant Professor, Department of Oral Pathology, Faculty of Dentistry, Tanta University, Egypt | ||
| 4Lecturer, Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Minia University, Egypt. | ||
| Abstract | ||
| Background: Potential pollution of air, water and land is a consequence of fertilizers industrial productions that have biohazardous impact on animal, human health and ecosystem. Aim: To investigate the clinical response and the levels of IL-6 and Nitric Oxide derivatives (nitrogen oxide) (NO ˚) after non-surgical periodontal therapy in chronic periodontitis patients working in fertilizers factory. Material and Methods: 60 subjects were included in the study. Forty chronic periodontitis male patients equally divided into 2 groups. Group І, 20 patients working in the fertilizers and chemical industries factory and group II, 20 patients did not work or live near any fertilizer factories. Twenty healthy volunteers not working in fertilizer factories were act as a control group (Group III). The Plaque Index (Pl-I), Gingival index (GI), Probing pocket depth (PD), and the Clinical Loss of Attachment (CLA) (clinical parameters) were scored for all subjects at baseline and one month after non-surgical periodontal therapy. Gingival Crevicular Fluid (GCF) samples were collected from all subjects, used for analysis by RT -PCR to assess the levels of IL -6 and Nitric Oxide derivatives (nitrogen oxide) (NO ˚) before (baseline) and one month after periodontal therapy. Results: One month after periodontal therapy, the two groups responded well to the non-surgical treatment but non-significant difference was observed (P>0.05). GI and Pl-I scores were reduced (P<0.001) with reduction in PD and gain in clinical attachment (P<0.05) in both groups. At baseline, the GCF mRNA levels of IL -6 and NO ˚ were higher in both studied groups when compared with the healthy group. But the levels were high in group I more than group II . The levels of mRNA for IL -6 and NO ˚ were significantly reduced after periodontal therapy in group I and II . A significant correlation between the levels of mRNA for IL -6 and NO ˚ derivatives with the clinical parameters mean scores at baseline and one month after periodontal therapy in both groups (P<0.05). Conclusion: Continuous exposure to fertilizers pollution did not affect the clinical response of non-surgical periodontal therapy but it affects the mRNA levels of free radicals NO ˚ and the pro-inflammatory cytokine IL -6 that lead to more destruction and worse outcomes of periodontal tissues. | ||
| Keywords | ||
| Periodontal therapy; fertilizers; IL-6; NO; Periodontitis | ||
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