Impact of antidepressant Duloxetine on the lingual mucosa of male albino rats (An ultrastructural, and imunohistoc hemical study) | ||
| Egyptian Dental Journal | ||
| Article 14, Volume 64, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2018, Pages 3417-3427 PDF (2.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2018.79098 | ||
| Authors | ||
| Rasha Mohamed Taha1; Rania Hanafi Mahmoud2 | ||
| 1Lecturer of Oral Biology Department, Faculty of Dentistry, Suez Canal University | ||
| 2Associated Professor of Oral Pathology Department, Faculty of Dentistry, Suez Canal University | ||
| Abstract | ||
| Objectives: This study was designed to clarify the effect of Duloxetine on the lingual mucosa of male albino rats. Materials and methods: Forty male albino rats divided as: 20 animals served as control. Group II: 20 animals and received duloxetine in a dose of 10mg/kg body weight that dissolved in distilled water and administrated through the metallic curved oropharngeal tube. At the end of the experiments, which lasts for 3 months, half of the animals of different groups (group I.1 and II.1) were sacrificed. The rest of animals (group I.2 and II .2) were allowed for a recovery period of 30 days. the tongue of all groups were extracted and prepared to examined through histological examination of their lingual mucosa to detect any structural changes, transmission electron microscopic examination of their lingual mucosa to detect any ultrastructural changes and immunohistochemical localization of E-cadherin Results: The light microscopic examination of the tongue of the rats treated with Duloxetine, anti-depressant drug, showed degenerative changes that involved the surface epithelium and lamina propria. The animals left for a recovery period showed partial improvement in their structure, these results were indicated by ultrastructural results. The immunohistochemical results of Duloxetine group showed weakly positive reactivity of E- cadherin while the recovery group showed moderately positive reactivity to E cadherin. Conclusion: Duloxetine has a degenerative effect upon the experimental level. | ||
| Keywords | ||
| Duloxetine; anti-depressant; Anxiety disorders; selective serotonin reuptake inhibitors | ||
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