Simultaneous Determination of Amlodipine and Rosuvastatin in Pharmaceutical Preparations by Square Wave Voltammetry | ||
| Journal of Advanced Pharmacy Research | ||
| Article 2, Volume 2, Issue 3, July 2018, Pages 162-167 PDF (366.15 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2018.3134.1052 | ||
| Authors | ||
| Bilal Yilmaz* ; Nurullah Yilmaz | ||
| Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey | ||
| Abstract | ||
| Objectives: In this work, a new, rapid, simple, precise and specific method has been developed for the simultaneous determination of amlodipine (AML) and rosuvastatin (ROS) in pharmaceutical preparations by square wave voltammetry (SWV). Methods: Electrochemical behavior and simultaneous voltammetric determination of AML and ROS were investigated using platinum disk electrode. Validation parameters such as specificity, linearity, accuracy, precision, ruggedness, stability, limit of quantification and limit of detection were studied according to the ICH Guidelines. Results: The linearity of this developed method was established in the concentration range of 5-40 μg/mL for AML and ROS, respectively. The precision was less than 1.88 and 1.93%, determined from quality control samples for AML and ROS, and accuracy was within 1.69 and 1.97% in terms of relative error, respectively. The percentage recovery obtained for AML and ROS in pharmaceutical preparations were 99.5 and 100.2%, respectively. Limit of detection and quantification for AML were 0.70 and 2.10 µg/mL, for ROS 0.80 and 2.40 µg/mL, respectively. Conclusion: The developed SWV method can be used for routine analysis of AML and ROS in pharmaceutical preparations. | ||
| Keywords | ||
| amlodipine; Rosuvastatin; Square wave voltammetry; validation | ||
|
Statistics Article View: 446 PDF Download: 704 |
||
