Hassan, A., El-Hakim, I., Amr, N., El-Ghoneimy, D., Soliman, D., Sallam, D. (2020). Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?. test, 18(1), 41-45. doi: 10.21608/ejpa.2020.81768
Ahmed Hassan; Ihab Z. El-Hakim; Nermine H. Amr; Dalia El-Ghoneimy; Dina A. Soliman; Dina E. Sallam. "Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?". test, 18, 1, 2020, 41-45. doi: 10.21608/ejpa.2020.81768
Hassan, A., El-Hakim, I., Amr, N., El-Ghoneimy, D., Soliman, D., Sallam, D. (2020). 'Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?', test, 18(1), pp. 41-45. doi: 10.21608/ejpa.2020.81768
Hassan, A., El-Hakim, I., Amr, N., El-Ghoneimy, D., Soliman, D., Sallam, D. Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?. test, 2020; 18(1): 41-45. doi: 10.21608/ejpa.2020.81768

Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?

The Egyptian Journal of Pediatric Allergy and Immunology
Article 6, Volume 18, Issue 1, April 2020, Pages 41-45    PDF (248.23 K)
Document Type: Original Article
DOI: 10.21608/ejpa.2020.81768
Authors
Ahmed Hassan* 1; Ihab Z. El-Hakim1; Nermine H. Amr2; Dalia El-Ghoneimy3; Dina A. Soliman4; Dina E. Sallam1
1Department of Pediatrics: Nephrology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2Endocrinology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Pediatric Allergy and Immunlogy Unit, Ain Shams University
4Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Introduction: Idiopathic nephrotic syndrome (INS), the most common form of NS in childhood, was considered 4 decades ago as a systemic disorder of T cells, mediated through its released cytokines. To date, the exact incriminated cytokine or immunological mediator is not properly defined. Interferon-gamma (IFN-gamma), a pro-inflammatory cytokine, is thought to have a role in the provocation of the T cell-mediated INS relapse, through the promotion of T helper1 (Th1) differentiation and suppression of regulatory T cells (Treg). Aim of the study: To evaluate the immunopathogenic role of IFN-gamma in children with steroid-sensitive idiopathic nephrotic syndrome (SSNS) through monitoring the changes in its levels with disease course. Methods: This study included twenty-five newly diagnosed children with SSINS. They were all given full dose prednisolone, evaluated at initial diagnosis and at full remission as regards the serum level of IFN-gamma. Results: Serum levels of IFN-gamma were lowermost at the time of diagnosis and increased with remission on corticosteroids. Conclusions: This study points to a role for the lower serum IFN-gamma at diagnosis, in the immunopathogenesis of INS than at remission and the rise in its serum level might be a marker of remission induction, however, this awaits confirmation in larger-scale studies. Studies on renal biopsy specimens are needed to determine the exact renal in situ levels and effects of IFN-gamma
Keywords
Idiopathic nephrotic syndrome; Steroid sensitive nephrotic syndrome; IFN-gamma
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