Effects of Activation of GHSR1a on Hepatic Fibrosis in Type 2 Diabetic Rats. | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 5, Volume 38, Issue 2, April 2022, Pages 149-164 PDF (821.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2018.8201 | ||
| Author | ||
| Mohamed Adel* | ||
| Department of Medical Physiology, Faculty of Medicine, Mansoura University, Egypt. | ||
| Abstract | ||
| Background: Diabetes is associated with nonalcoholic liver disease, steatohepatitis, and liver cirrhosis with their increased complications. In the current study, ghrelin, the agonist of GHS-R 1a was investigated.Materials and Methods: thirty rats were randomly divided into: control negative, control positive (Diabetic) and acylated ghrelin + T2DM groups each has 10 rats. Serum glucose and insulin, and also, triglyceride to high density lipoproteins (TG: HDL) ratio of all rats were measured to confirm the development of T2DM. Measurement of oxidative stress biomarkers in liver homogenate were performed. Results: In the diabetic group that received ghrelin, tissue MDA levels were significantly lower than in the diabetic group. Moreover, serum AST and ALT levels were higher in the diabetic group, but there was a significant decrease in the ghrelin-treated group. These results suggested that GHSR-1a can protect the liver of diabetic rats against the oxidative stress effects. Conclusion: the antioxidant activity of ghrelin could attenuate diabetic-induced liver fibrosis. | ||
| Keywords | ||
| GHS-R; T2DM; ghrelin; Oxidative Stress | ||
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