Bezafibrate Scaffold Derived Hydrazide-Hydrazones: Synthesis and Antioxidant Activities | ||
| Egyptian Journal of Chemistry | ||
| Article 6, Volume 63, Issue 7, July 2020, Pages 2473-2482 PDF (1.14 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2020.20809.2251 | ||
| Authors | ||
| HARI BABU Bollikolla* 1; Ramya Krishna p2; sailaja g3; Umamaheswara rao vanga4 | ||
| 1DEPT. OF CHEMISTRY, ACHARYA NAGARJUNA UNIVERSITY, NNAGAR,AP-INDIA | ||
| 2dept. of chemistry, acharya nagarjuna university, guntur | ||
| 3dept. of chemistry, Singareni Collieries Women’s Degree College, Kothagudem-507101, Telangana, India | ||
| 4Department of Microbiology, Acharya Nagarjuna University, nnagar, Guntur-522510, AP., India | ||
| Abstract | ||
| A new series of Bezafibrate derived hydrazide-hydrazone analogues were generated by using some five membered, fused heterocyclic and aromatic aldehydes. All the hydrazones were obtained in good yields from methanol at 60-80 °C for 5-8 hours stirring. Moreover, the compounds were also screened after their anti-oxidant activity potentiality at four different concentrations using DPPH method. Among these compounds, compound 6k analogue of bezafibrate was found to be the most active at all the tested concentrations (≈ 40% inhibition at 25 μg/mL ) followed by 6j (4-hydroxy, 3-methoxy 5-bromo analogue ≈ 35% at 25 μg/mL) compared to standard ascorbic acid (49.6% at 25 μg/mL). | ||
| Keywords | ||
| Bezafibrate; hydrazide-hydrazone; antioxidant; ascorbic acid | ||
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