Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 7, Volume 38, Issue 2, April 2022, Pages 175-184 PDF (850.06 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2018.8206 | ||
| Authors | ||
| Azza Elamir* 1; Tarek Ibrahim2; Nermeen A. Fouad3; Mohamed Masoud4 | ||
| 1Department of Medical Biochemistry, Faculty of Medicine, Fayoum University, Fayoum, Egypt. | ||
| 2Department of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt. | ||
| 3Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Fayoum, Egypt. | ||
| 4Department of public health, Faculty of Medicine, Fayoum University, Fayoum, Egypt. | ||
| Abstract | ||
| Aim: This study was designed to measure the serum level of vitamin D in patients with rheumatoid arthritis, and to correlate it with disease activity. Method: 41 patients of Rheumatoid arthritis fulfilling the ACR/EULAR classification criteria for RA and 20 healthy controls were included in the study. Disease activity was evaluated by DAS-28 score. 25 (OH) vitamin D and CRP levels were measured using ELISA Kit. Results: 9 patients had high disease activity (DAS-28 score >5.1), 25 patients had moderate disease activity (DAS 28 score 3.2-5.1, group B) and 7 patients had low disease activity (DAS-28 score ≤ 3.2). Mean serum level of vitamin D of RA patients was significantly low compared to healthy controls (P<0.0001). There was statistically significant negative correlation between vitamin D and DAS-28 (r = -0.388, P = 0.031). Conclusion: Serum level of vitamin D of RA patients was significantly low compared to healthy controls and vitamin D had statistically significant negative correlation with disease activity in RA. | ||
| Keywords | ||
| Rheumatoid Arthritis; Vitamin D | ||
|
Statistics Article View: 350 PDF Download: 412 |
||
