Askar, E., Selim, S., Sibai, H. (2019). Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia. test, 3(1), 65-76. doi: 10.21608/jmh.2019.12648.1056
Eman Askar; Sally Selim; Hoda Sibai. "Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia". test, 3, 1, 2019, 65-76. doi: 10.21608/jmh.2019.12648.1056
Askar, E., Selim, S., Sibai, H. (2019). 'Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia', test, 3(1), pp. 65-76. doi: 10.21608/jmh.2019.12648.1056
Askar, E., Selim, S., Sibai, H. Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia. test, 2019; 3(1): 65-76. doi: 10.21608/jmh.2019.12648.1056

Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia

Journal of Medical Histology
Article 5, Volume 3, Issue 1, June 2019, Pages 65-76    PDF (2.53 M)
Document Type: Original Article
DOI: 10.21608/jmh.2019.12648.1056
Authors
Eman Askar1; Sally Selim* 1; Hoda Sibai2
1Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
2Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: Intra uterine growth restriction (IUGR) is a common pregnancy complication, pre-eclamsia (PE) is an important
cause of this complication and is responsible for maternal and fetal morbidity and mortality. Idiopathic intrauterine growth
restriction without obvious causes is not uncommon.
Objective: The aim of this study is to examine the placental histology in both conditions trying to find specific criteria for each
disorder.
Materials and Methods: This study was conducted on three groups; group I was the control group, group II was preeclampsia
induced IUGR (PE-IUGR) group and group III was idiopathic IUGR (I-IUGR). Each group contained 15 placentas. Placental
specimens from each group were analyzed histopathologically and immunohistochemically.
Results: we found that PE-IUGR and I-IUGR cases in this study share common histological changes suggesting a similar
pathogenesis. Maternal mal-perfusion lesions predominated in PE-IUGR. Findings consistent with fetal vascular malperfusion
were higher in I-IUGR. Hofbauer cells (HBC) were increased in both PE-IUGR and I-IUGR.
Conclusion: abnormal utero-placental blood vessels and utero-placental insufficiency and the resulting histological changes in
the chorionic villi, and chronic inflammatory lesions may be the primary disease processes related to the placental pathology
of PE-IUGR and I-IUGR.
Keywords
Decidual vasculopathy; fetal vascular obstruction intrauterine growth restriction; placenta; preeclampsia
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