Clinical presentation and surgical management of Glomatosis Cerebri | ||
| International Journal of Sustainable Development and Science | ||
| Article 7, Volume 1, Issue 2, June 2018, Pages 1-14 PDF (610.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijsrsd.2018.8536 | ||
| Authors | ||
| Mohamed Youssef ALQazaz1; Mohamed Mohamed Elsamahy* 2 | ||
| 1Assistant professor of Neurosurgery, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||
| 2Suez Canal University,Ismailia,Department of Neurology,Egypt | ||
| Abstract | ||
| Background: Glomatosis Cerebri (GC) is a diffuse brain neoplasm whose prognosis is unfavourable. Aim: to investigate the clinical presentation, radiological and pathological features, and outcomes after treatment of GC. Patients and Methods: We collected data from fifteen patients with GC treated at Suez Canal University, during a ten-year period. The diagnosis was based on magnetic resonance imaging (MRI) findings and tissue biopsy of all patients except one patient who received blind radiotherapy. Results: Seven patients were male (47%), and their median age at presentation was 43 years (range, 6 75 years). Statistical analysis demonstrated median survival as follows: blind radiotherapy, 1 month (n = 1); biopsy then radiotherapy, 19 months (8 32 months; n = 9); subtotal excision then radiotherapy, 5 months (1-7 months; n=5). Karnofsky Performance Scale scores of 70 and tumor grade were both significantly related to length of survival. Conclusion: Our findings suggest that biopsies are useful not only for diagnosis but also for prediction of the length of survival. | ||
| Keywords | ||
| GC; Outcome; Biopsy; Radiotherapy | ||
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