Pharmacokinetics of a Once Daily Dosing Regimen of Gentamicin in a Patient with Delayed Wound Healing | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 19, Volume 71, Issue 6, April 2018, Pages 3386-3389 PDF (319.52 K) | ||
| Document Type: Original Article | ||
| Author | ||
| Saeed F Algahtani1, Fahad M AlQahtani2, Mohammed Qahl3 | ||
| 1. Department of Clinical Pharmacy, Al Kharj Military Industries Corporation Hospital, 2. Drug Information and Poisoning Center, Al Kharj Military Industries Corporation Hospital,3. Department of Pharmacy, Northern Area Armed Forces Hospital | ||
| Abstract | ||
| Background: Gentamicin is used for the treatment of serious gram-negative infections and has low therapeutic index. This may lead to several side effects, though therapeutic drug monitoring (TDM) is important in gentamicin therapy. Aim: To report the pharmacokinetics of gentamicin using a once-daily dosing regimen. Clinical presentation and intervention: The patient was a 78-year-old male. His weight was 78 kg and he was 1.75 m in height. He was admitted to the hospital complaining of an infected wound secondary to chronic limb ischaemia. Once-daily dosing of gentamicin (360 mg by infusion over 30 minutes) was prescribed to this patient, in combination with flucloxacillin. A gentamicin blood sample was taken every day for four days (day 1 = 1.4 mg/L, day 2 = 2.1 mg/L, day 3 = 2.1 mg/L, day 4 = 1.6 mg/L). The patient’s serum creatinine was 88 μmol/L during the four days. The Hartford nomogram was used to estimate the dosage and interval for administration of gentamicin. Conclusion: The Hartford nomogram is a valid tool to monitor the once-daily dosing regimen of gentamicin. | ||
| Keywords | ||
| Pharmacokinetics; Dosing Regimen; gentamicin; Wound healing | ||
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