Gad, E., Atef Gouda, A., Ghany, M., Raafat, N. (2020). Effect of Sulphonylurea Derivatives and Short Chain Fatty Acids on Expression of Incretins Hormone in living Animal Cells. test, 20(1), 69-76. doi: 10.21608/cat.2020.85796
Emad Gad; Atef Atef Gouda; Mohamed A Ghany; Nermin Raafat. "Effect of Sulphonylurea Derivatives and Short Chain Fatty Acids on Expression of Incretins Hormone in living Animal Cells". test, 20, 1, 2020, 69-76. doi: 10.21608/cat.2020.85796
Gad, E., Atef Gouda, A., Ghany, M., Raafat, N. (2020). 'Effect of Sulphonylurea Derivatives and Short Chain Fatty Acids on Expression of Incretins Hormone in living Animal Cells', test, 20(1), pp. 69-76. doi: 10.21608/cat.2020.85796
Gad, E., Atef Gouda, A., Ghany, M., Raafat, N. Effect of Sulphonylurea Derivatives and Short Chain Fatty Acids on Expression of Incretins Hormone in living Animal Cells. test, 2020; 20(1): 69-76. doi: 10.21608/cat.2020.85796

Effect of Sulphonylurea Derivatives and Short Chain Fatty Acids on Expression of Incretins Hormone in living Animal Cells

Catrina: The International Journal of Environmental Sciences
Article 8, Volume 20, Issue 1, April 2020, Pages 69-76    PDF (1.14 M)
Document Type: Original Article
DOI: 10.21608/cat.2020.85796
Authors
Emad Gad1; Atef Atef Gouda2; Mohamed A Ghany1; Nermin Raafat2
1Chemistry Department, Faculty of Science, Suez Canal University, Egypt
2Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Egypt
Abstract
Dietary fibres are a type of carbohydrates that are found in plant-based foods. They are not absorbed or digested by the body but play an important role in maintaining good health. Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are metabolites formed by gut microbiota from these complex dietary carbohydrates. The formed acids have a role in the secretion of hormones such as glucagon-like peptide-1(GLP-1) and glucose-dependent insulin tropic polypeptide (GIP) that help the body to control diabetes. Diabetes mellitus is a chronic disease that occurs when the pancreas fails to produce enough insulin, or when the body cannot use it effectively. The hormones GLP-1 and GIP, which secreted after a meal, like other enteroendocrine hormones help to orchestrate the body's response to the availability of newly absorbable nutrients and are noteworthy, stimulate postprandial insulin secretion. This study clarifies the effects and the roles of organic compounds such as Short Chain Fatty Acids (SCFAs) and sulphonylurea derivatives on body glucose homeostasis and clarifies the effects of both SCFAs and sulphonylurea on incretin expression by investigating the expression of GLP-1 and GIP hormones in tissues and blood samples.
Keywords
Microbiota; Enteroendocrine hormones; Sulphonylurea derivatives; glucagon–like peptide-1(GLP-1)
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