ATIA, M., ABDUL FATTAH, M., ABDEL RAHMAN, H., MOHAMMED, F., AL GHANDOUR, A. (2016). ASSESSING THE EFFICACY OF NITAZOXANIDE IN TREATMENT OF CRYPTOSPORIDIOSIS USING PCR EXAMINATION. test, 46(3), 683-692. doi: 10.21608/jesp.2016.88325
MOHMMAD M. ATIA; MOHIEDDIN M. ABDUL FATTAH; HANAN AMIN ABDEL RAHMAN; FATEN A. MOHAMMED; ASMAA M. AL GHANDOUR. "ASSESSING THE EFFICACY OF NITAZOXANIDE IN TREATMENT OF CRYPTOSPORIDIOSIS USING PCR EXAMINATION". test, 46, 3, 2016, 683-692. doi: 10.21608/jesp.2016.88325
ATIA, M., ABDUL FATTAH, M., ABDEL RAHMAN, H., MOHAMMED, F., AL GHANDOUR, A. (2016). 'ASSESSING THE EFFICACY OF NITAZOXANIDE IN TREATMENT OF CRYPTOSPORIDIOSIS USING PCR EXAMINATION', test, 46(3), pp. 683-692. doi: 10.21608/jesp.2016.88325
ATIA, M., ABDUL FATTAH, M., ABDEL RAHMAN, H., MOHAMMED, F., AL GHANDOUR, A. ASSESSING THE EFFICACY OF NITAZOXANIDE IN TREATMENT OF CRYPTOSPORIDIOSIS USING PCR EXAMINATION. test, 2016; 46(3): 683-692. doi: 10.21608/jesp.2016.88325

ASSESSING THE EFFICACY OF NITAZOXANIDE IN TREATMENT OF CRYPTOSPORIDIOSIS USING PCR EXAMINATION

Journal of the Egyptian Society of Parasitology
Article 25, Volume 46, Issue 3, December 2016, Pages 683-692    PDF (307.35 K)
Document Type: Original Article
DOI: 10.21608/jesp.2016.88325
Authors
MOHMMAD M. ATIA1; MOHIEDDIN M. ABDUL FATTAH1; HANAN AMIN ABDEL RAHMAN2; FATEN A. MOHAMMED1; ASMAA M. AL GHANDOUR1
1Departments of Medical Parasitology، Faculty of Medicine, Zagazig University, Sharkia Egypt
2Department of Pediatrics, Faculty of Medicine, Zagazig University, Sharkia Egypt.
Abstract
Cryptosporidiosis is a gastrointestinal disease of humans and other animals, caused by the genus Cryptosporidium spp. It causes persistent diarrhea and malnutrition and is associated with increased mortality. This study aimed to assess the efficacy of nitazoxanide (NTZ) on clearing the oocysts of C. parvum among infected children using both parasitological and PCR techniques. 120 children (1-12y) shedding Cryptosporidium oocysts in their stools were enrolled in the study. They were classified on the basis of the immune status into immunocompetent (ICT) and immunocompromised (ICZ) groups. Each group were subdivided into two groups one of them received NTZ, and the other received placebo. The efficacy of nitazoxanide was assessed clinically, parasitologically and by nested-PCR technique. At the end of 1st week of treatment,
80% of ICT/ NTZ group and 40% of ICT/ placebo group were free by PCR and 83.3% & 20% respectively were microscopically free. While at the end of 4th week, 93.3% of ICT/ NTZ group and 43.3% of ICT/ placebo group were free by PCR and 96.7% & 26.7% respectively were microscopically free. Among the ICZ group, diarrhea was resolved in most patients receiving NTZ within 21 to 28 days of treatment initiation While, it resolved in the ICT group receiving
NTZ in most patients within 3 to 5 days of treatment initiation
Keywords
Nitazoxanide; Cryptosporidiosis; immunocompromised; PCR; Treatment
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