Nouh, A., Kassem, M., Kassem, A., Elmahrouk, G. (1984). PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS. test, 7(1), 47-61. doi: 10.21608/bfsa.1984.89521
A. T. Nouh; M. A.A. Kassem; Alaa A. Kassem; G. Elmahrouk. "PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS". test, 7, 1, 1984, 47-61. doi: 10.21608/bfsa.1984.89521
Nouh, A., Kassem, M., Kassem, A., Elmahrouk, G. (1984). 'PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS', test, 7(1), pp. 47-61. doi: 10.21608/bfsa.1984.89521
Nouh, A., Kassem, M., Kassem, A., Elmahrouk, G. PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS. test, 1984; 7(1): 47-61. doi: 10.21608/bfsa.1984.89521

PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS

Bulletin of Pharmaceutical Sciences Assiut University
Article 4, Volume 7, Issue 1, June 1984, Pages 47-61    PDF (431.49 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1984.89521
Authors
A. T. Nouh1; M. A.A. Kassem2; Alaa A. Kassem3; G. Elmahrouk2
1Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
2Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
3Faculty of Pharmacy, El-Azhar University
Abstract
Eudragits S, L, RL and mixture of S and L were employed for prolonging the release of ephedrine hydrochloride from tablets by two different techniques, viz, spray coating and molecular dispersion. The in-vitro dissolution rate evaluation in both acid and alkaline media revealed that, tablets prepared with Eudragit-L showed the most prolonged release with t20% of 3½ and 4½ hours for spray coating and molecular dispersion methods respectively. Concerning the technique itself; drug-Eudragit molecular dispersion system showed a slower release than spray coating.
Higuchi model for drug release could be applied for the release pattern only for few hours in case of tablets containing coated drug, while it absolutely explains the release from tablets having drug-Eudragit molecular dispersion system. Release was found to proceed according to order kinetics.
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