MANUFACTURE AND DISSOLUTION CHARACTERISTICS OF NEOMYCIN SULPHATE TABLETS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 6, Volume 7, Issue 1, June 1984, Pages 75-96 PDF (610.71 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1984.89530 | ||
| Authors | ||
| M. A.A. Kassem; M. El-Khatib | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Some direct compression vehicles, viz., Avicel PH 101, Celutab, Sta-Rx 1500 Starch, Emcomress, and Solka-floc were employed in different concentrations for the preparation of neomycin sulphate tablets. The physical properties of the produced tablets were determined. The effect of incorporation of the different excipients on the dissolution characteristics of neomycin sulphate have been investigated. Neomycin sulphate tablets were successfully prepared by mixing with the suggested vehicles and drying before compression. Of the used vehicles, Celutab and Emcompress proved to be the best in improving the mechanical properties of the produced tablets. This improvement increased on increasing the proportion of the excipient. On the other hand, Avicel in spite of producing tablets having high hardness and low friability values, extended the disintegration time of the tablets. The drug dissoluted from these tablets very rapidly, but the rate decreased on increasing Avicel proportion. | ||
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