MONITORING OF THE ANTIVIRAL POTENTIAL OF BEE VENOM AND WAX EXTRACTS AGAINST ADENO-7 (DNA) AND RIFT VALLEY FEVER VIRUS (RNA) VIRUSES MODELS | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 23, Volume 45, Issue 1, April 2015, Pages 193-198 PDF (206.18 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2015.89742 | ||
| Authors | ||
| MOSTAFA I. HASSAN; ALY F. Mohamed; MONER A. AMER; KOTB M. HAMMAD; SABER A. RIAD | ||
| Department of Zoology, Faculty of Science, Al-Azhar University, Egypt. | ||
| Abstract | ||
| This study monitored the antiviral potential of bee venom and four wax extracts, ethanol white and black beeswax (EWW/EBW) and acetone white and black beeswax (AWW/ABW) extracts. Two different virus models namely Adeno-7 as DNA model and RVFV as RNA virus models. End point calculation assay was used to calculate virus depletion titer. The depletion of viral infectivity titer of ABW to Adeno-7 virus showed strong antiviral activity recorded a depletion of viral infectivity titer (1.66 log (10)/ ml) that gave equal action with bee venom and more than interferon IFN (1 log (10)/ ml). On the other hand, antiviral activity of EBW showed a moderate potential, while AWW showed no antiviral activity. Finally EWW showed synergetic activity against Adeno-7 virus activity. Thus, activity of wax extracts to RVFV was arranged in order of IFN > bee venom > AWW & EBW > EWW and ABW recorded 3.34, 0.65, 0.5, 0.34 respectively. It is the first time to study the beeswax effect against DNA and RNA virus’ models; acetone black beeswax recorded a depletion titer 1.66 log (10)/ ml. | ||
| Keywords | ||
| Bee venom; Bee's wax; Antiviral; Cytopathology; DNA & RNA virus models | ||
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