MODULATION OF TUBERCULOSIS-RELATED IMMUNE RESPONSES BYHELMINTHS | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 14, Volume 44, Issue 1, April 2014, Pages 141-144 PDF (175.29 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2014.90720 | ||
| Author | ||
| P. MÉNDEZ-SAMPERIO | ||
| Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, IPN. Prol. Carpio y Plan de Ayala, México, D.F. 11340 México. | ||
| Abstract | ||
| Tuberculosis (TB) continues to be a major worldwide health problem, with 9.4 million newly emerging active tuberculosis cases and causes nearly 2 million deaths annually. Currently, experimental evidence for an strong association between helminths and diminished T helper (Th)1 immunity against Mycobacterium tuberculosis infection is based on studies which show that helminth-induced Th2, T regulatory (Treg) responses and alternatively activated macrophages contribute to enhanced susceptibility to TB. In this context, it has been shown that Th1 response is reduced in helminth coinfected TB patients. This article discusses what is presently known about the types of immune responses modulated by helminths to diminish the protective immune response to TB. | ||
| Keywords | ||
| Helminths; immune responses; tuberculosis | ||
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