ABDELMOEZ, A., ZAKY, D., MAHER, A. (2014). ROLE OF CEREBROSPINAL FLUID IL-8 AS A MARKER FOR DIFFERENTIATION BETWEEN ACUTE BACTERIAL AND ASEPTIC MENINGITIS. test, 44(1), 205-210. doi: 10.21608/jesp.2014.90739
AMAL TOHAMY ABDELMOEZ; DOAA ZAKARIA ZAKY; AMANY M. MAHER. "ROLE OF CEREBROSPINAL FLUID IL-8 AS A MARKER FOR DIFFERENTIATION BETWEEN ACUTE BACTERIAL AND ASEPTIC MENINGITIS". test, 44, 1, 2014, 205-210. doi: 10.21608/jesp.2014.90739
ABDELMOEZ, A., ZAKY, D., MAHER, A. (2014). 'ROLE OF CEREBROSPINAL FLUID IL-8 AS A MARKER FOR DIFFERENTIATION BETWEEN ACUTE BACTERIAL AND ASEPTIC MENINGITIS', test, 44(1), pp. 205-210. doi: 10.21608/jesp.2014.90739
ABDELMOEZ, A., ZAKY, D., MAHER, A. ROLE OF CEREBROSPINAL FLUID IL-8 AS A MARKER FOR DIFFERENTIATION BETWEEN ACUTE BACTERIAL AND ASEPTIC MENINGITIS. test, 2014; 44(1): 205-210. doi: 10.21608/jesp.2014.90739

ROLE OF CEREBROSPINAL FLUID IL-8 AS A MARKER FOR DIFFERENTIATION BETWEEN ACUTE BACTERIAL AND ASEPTIC MENINGITIS

Journal of the Egyptian Society of Parasitology
Article 21, Volume 44, Issue 1, April 2014, Pages 205-210    PDF (213.32 K)
Document Type: Original Article
DOI: 10.21608/jesp.2014.90739
Authors
AMAL TOHAMY ABDELMOEZ1; DOAA ZAKARIA ZAKY1; AMANY M. MAHER2
1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo11566, Egypt.
2Medical Research Center, Molecular Biology Unit, Ain Shams University, Cairo11566, Egypt.
Abstract
No doubt, the distinguishing between bacterial and aseptic meningitis in the emergency department could help to limit unnecessary antibiotic use and hospital admissions. This study evaluated the role of cerebrospinal fluid IL-8 in differentiating acute bacterial meningitis (ABM) from aseptic meningitis (AM). A total of 80 hospitalized patients with clinical presentations of suspected acute meningitis were subjected to estimation of IL-8 CSF concentrations. The results showed that CSF IL-8 levels were higher in acute bacterial meningitis than in aseptic ones (p <0.05). The best cut-off value of CSF IL8 for early diagnosis of bacterial meningitis was 3.6ng/ml with a sensitivity of 82.5% and a specificity of
85.0%.
Keywords
Egypt; Acute Bacterial; Aseptic Meningitis; Marker; Cerebrospinal Fluid Il-8
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