Changes in intraocular pressure after intravitreal injection of ranibizumab | ||
| NILES journal for Geriatric and Gerontology | ||
| Article 4, Volume 3, Geriatric ophthalmology, May 2020, Pages 23-28 PDF (1.04 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/niles.2020.26776.1009 | ||
| Authors | ||
| Mohamed Yasser Sayed SAIF1, 2; Khaled Abd ElAziz Abd El Hafez3; Asmaa Mohamed Fouad* 4 | ||
| 1Ophthalmology department , Faculty of Medicine , Beni-Suef University | ||
| 2NILES , Beni-Suef University | ||
| 3Faculty of medicine_Benisuef University | ||
| 4Faculty of medicine-BeniSuef University BeniSuef | ||
| Abstract | ||
| The aim of this study was to detect changes in intraocular pressure(IOP) following initial intravitreal injection of antivascular endothelial growth factor agents anti-VEGF ranibizumab in patients presenting with macular edema due to diabetes mellitus (DM), age- related macular degeneration(ARMD) , retineal vein occlusion(RVO), and myopic choroidal neovascularization (CNV) . Methods:In this study,a prospective analysis was conducted on 40 eyes of 40 patients. IOP was measured using a goldmann applanation tonometer before injection, 24 h, 1st and weekly up to 8 weeks after injection . Patients were scheduled for intravitreal injection of anti-VEGF ranibizumab (0.5 mg/0.05 ml) for the treatment of macular edema due to(DM), (RVO), (ARMD) ,and (CNV). Results: It was fоund that there was a significant difference, but still within the normal range value in IOP measured 24 h after injection(14.2±3.54 mmHg and ranged from (9 : 22 mmHg)) compared to baseline (p = 0.001) . There was no significant difference between the IOP from 1 week up to 8W of ranibizumab injection. Conclusion: This study confirms the results of previous studies that showed the safety of initial IV injection of anti-VEGF agents for IOP elevation in post-injection two monthes in non- glaucomatous patients. | ||
| Keywords | ||
| Intraocular; pressure; ranibizumab | ||
| References | ||
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1.Saif ATS, Saif PS , El Deeb A. Role of amniotic membrane transplantation in symblepharon. Guoji Yanke Zazhi(Int Eye Sci) 2017;17(5):819-824 2.Nassar M, Saif M, Saif A, Saif P. Sensitivity and specificity of nassar color test in early detection of diabetic macular edema. Journal of Retina-Vitreous. 2016;24:109-113. 3.Amer, S. , Saif, M. , Saif, A. and Saif, P. (2014) Variations of Cup-to-Disc Ratio in Children. Open Journal of Ophthalmology, 4, 12-17. doi: 10.4236/ojoph.2014.41003. | ||
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