Elbably, M., Abd elhamid, O., ElNahas, E. (2019). Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats. test, 37(1), 223-228. doi: 10.21608/bvmj.2019.17934.1109
Marwa Elbably; Omnia Abd elhamid; Ehab ElNahas. "Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats". test, 37, 1, 2019, 223-228. doi: 10.21608/bvmj.2019.17934.1109
Elbably, M., Abd elhamid, O., ElNahas, E. (2019). 'Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats', test, 37(1), pp. 223-228. doi: 10.21608/bvmj.2019.17934.1109
Elbably, M., Abd elhamid, O., ElNahas, E. Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats. test, 2019; 37(1): 223-228. doi: 10.21608/bvmj.2019.17934.1109

Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats

Benha Veterinary Medical Journal
Article 45, Volume 37, Issue 1, September 2019, Pages 223-228    PDF (791.11 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2019.17934.1109
Authors
Marwa Elbably* 1; Omnia Abd elhamid1; Ehab ElNahas2
1Biochemistry Department, Faculty of Veterinary Medicine Banha University
2Virology Department, Faculty of Veterinary Medicine Banha University
Abstract
This study evaluated the effect of Sukkari date extract on STZ induced diabetes in male rats. forty male albino rats were divided into 2 main groups: Group I ( Control): Consists of 10 rats act as normal control. Group II (STZ) : Consists of 30 rats injected with a single dose of STZ (50 mg/kg b.wt ; i.p) for induction of diabetes and after 48hr divided into 3 subgroups (10 each ):Subgroup a : Diabetic rats not treated and act as diabetic control .Subgroup b: Diabetic rats administrated with aqueous sukkari date extract at a dose of 10 ml/day orally for 60 days.Subgroup c : Diabetic rats treated with Amaryl tablets at a dose of 1ml / rat / day orally for 60 days. Blood samples were collected after 60 days from treatment . Determination of (Glucose , Lipid profile , Insulin , MDA, SOD and 8-hydroxy-2-deoxyguanosine(8-OHdG) , Inaddition paraoxonase 1 (PON1) was estimated in Liver tissue . STZ injected rats showed a significant increase in serum Glucose, cholesterol , triglyceride , LDL ,MDA and 8-OHdG level, with significant decrease in insulin , HDL and SOD levels.Moreover a significant downregulaion of PON1 in liver homogenate. Treatment of diabetic rats with aqueous sukkari date extract or amaryl showed a significant ameliorate in all parameters nearly normal level that indicated the hypoglycemic, hypolipidemic and antioxidative damage effect of aqueous sukkari date extract .
Keywords
Sukkari date; D. M; streptozotocin; 8-OHdG; PON1 PCR
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