EVALUATION OF CYCLODEXTRIN (SUGAMMADEX) FOR REVERSAL OF INTENSE NEUROMUSCULAR BLOCK OF ROCURONIUM AND VECURONIUM, EXPERIMENTAL AND CLINICAL STUDIES | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 15, Volume 43, Issue 3, December 2013, Pages 705-714 PDF (251.16 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2013.93317 | ||
| Author | ||
| HATEM M. NASR ALKENANY | ||
| Department of Anesthesia and ICU, Faculty of Medicine, Al-Azhar University, Nasr City, Cairo, Egypt. | ||
| Abstract | ||
| This study evaluated and explored time course, efficacy, relation, safety, changes in heart rate, and blood pressure after a bolus dose of sugammadex or neostigmine for reversal of a prolonged rocuronium and vecuronium induced neuromuscular block. A total of 60 patients of both sexes, ‘ASA’ grade I, II and all were scheduled for elective surgery of 30-45 minutes duration. Informed oral consent was obtained from all patients to participate in this study. The results showed statistically significant progressive decrease of heart rate and blood pressure at 2, 5 and 10 minutes when compared to their basal values before anesthesia, then it starts to gain its normal value at 5 and 10 minutes, regardless the dose of sugammadex (effect of anesthesia). Also, heart rate and blood pressure showed statistically non-significant variance between groups of sugammadex when compared at any time of the study with the neostigmine groups (i.e. no effect of the dose on heart rate). | ||
| Keywords | ||
| Cyclodextrin; Rocuronium; Vecuronium; In-vitro; In-vivo studies | ||
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