Khalid, R., Nasiri, M., Sarwar, H., Yasmin, R., Zaheer, K., Anwer, S., Fatima, A. (2020). INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE. test, 43(1), 11-25. doi: 10.21608/bfsa.2020.93530
Rida Khalid; Muhammad Iqbal Nasiri; Humera Sarwar; Riffat Yasmin; Kamran Zaheer; Sohail Anwer; Anab Fatima. "INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE". test, 43, 1, 2020, 11-25. doi: 10.21608/bfsa.2020.93530
Khalid, R., Nasiri, M., Sarwar, H., Yasmin, R., Zaheer, K., Anwer, S., Fatima, A. (2020). 'INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE', test, 43(1), pp. 11-25. doi: 10.21608/bfsa.2020.93530
Khalid, R., Nasiri, M., Sarwar, H., Yasmin, R., Zaheer, K., Anwer, S., Fatima, A. INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE. test, 2020; 43(1): 11-25. doi: 10.21608/bfsa.2020.93530

INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 43, Issue 1, June 2020, Pages 11-25    PDF (1.3 M)
Document Type: Original Article
DOI: 10.21608/bfsa.2020.93530
Authors
Rida Khalid1; Muhammad Iqbal Nasiri2; Humera Sarwar1; Riffat Yasmin3; Kamran Zaheer1; Sohail Anwer1; Anab Fatima3
1Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan
2Department of Pharmaceutics, Hamdard Institute of Pharmaceutical Sciences, Hamdard University, Islamabad, Pakistan
3Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan
Abstract
The objectives of the current study were to investigate the influence of different types and concentration of polymers on release of ciprofloxacin HCl as well as to formulate an extended release tablets of ciprofloxacin hydrochloride by direct compression method. Twelve formulations (F1–F12) were manually designed using different proportions (10–30%) of Hydroxypropyl methylcellulose (HPMC), Ethylcellulose (EC) and Kollidon SR polymers. Avicel PH101, talc and magnesium stearate were used in a constant quantity of 2% in all the formulations. Multiple point dissolution was carried out in different media. Dissolution profiles indicated that formulations F1, F4, F8 and F11, extended the drug release up to 12 hrs, while, other formulations failed to retard the drug release up to desired period. DDSolver software was used to analyze the dissolution profile data for drug release kinetics such as first order, Zero-order, Korsmeyer–Peppas and Higuchi models. Drug polymers compatibility was assessed using Fourier Transformed Infrared (FTIR) spectroscopy. Selected formulations were placed in the stability chamber at accelerated temperature (40±2°C and RH 75±5%) for six months and re-evaluated after 3 and 6 months as per ICH guidelines. The present study accomplished that ethylcellulose alone or in combination with HPMC was found to be an excellent rate controlling agent for ciprofloxacin and may be used successfully to develop extended release tablet formulations.
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