Shawky, M., Mohamed, A., Daoud, H., Farouk, E. (2013). Comparative Studies Between Intramuscular And Subcutaneous Vaccination Of Sheep Using Different Doses Of Bivalent Oil Adjuvant Foot And Mouth Disease Vaccine. test, 41(1), 200-206. doi: 10.21608/zvjz.2013.94480
ME Shawky; AA Mohamed; Hind Daoud; Ekbal M Farouk. "Comparative Studies Between Intramuscular And Subcutaneous Vaccination Of Sheep Using Different Doses Of Bivalent Oil Adjuvant Foot And Mouth Disease Vaccine". test, 41, 1, 2013, 200-206. doi: 10.21608/zvjz.2013.94480
Shawky, M., Mohamed, A., Daoud, H., Farouk, E. (2013). 'Comparative Studies Between Intramuscular And Subcutaneous Vaccination Of Sheep Using Different Doses Of Bivalent Oil Adjuvant Foot And Mouth Disease Vaccine', test, 41(1), pp. 200-206. doi: 10.21608/zvjz.2013.94480
Shawky, M., Mohamed, A., Daoud, H., Farouk, E. Comparative Studies Between Intramuscular And Subcutaneous Vaccination Of Sheep Using Different Doses Of Bivalent Oil Adjuvant Foot And Mouth Disease Vaccine. test, 2013; 41(1): 200-206. doi: 10.21608/zvjz.2013.94480

Comparative Studies Between Intramuscular And Subcutaneous Vaccination Of Sheep Using Different Doses Of Bivalent Oil Adjuvant Foot And Mouth Disease Vaccine

Zagazig Veterinary Journal
Article 19, Volume 41, Issue 1, March 2013, Pages 200-206    PDF (2.52 M)
Document Type: Original Article
DOI: 10.21608/zvjz.2013.94480
Authors
ME Shawky1; AA Mohamed1; Hind Daoud2; Ekbal M Farouk2
1Foot and Mouth Department, Veterinary serum and vaccines research institute, Abbassia, Cairo
2Foot and Mouth Department, Veterinary serum and vaccines research institute, Abbassia, Cairo,
Abstract
Aim: The aim of this study was to investigate whether subcutaneous (S/C) or intramuscular (I/M) is better in vaccination against foot-and mouth disease (FMD), in addition, to determination of the most protective dose concerning the economic point of view.
Forty  animals were divided into ten groups ,each group eight of sheep were vaccinated with different doses of the bivalent oil FMD vaccine (with 1 ml, 0.5 ml, 0.25 ml and 0.125 ml doses) either S/C or I/M. The experiment included challenged non-vaccinated control group and non-challenged-non-vaccinated control groups. Four weeks post vaccination all animal groups were challenged by inoculation intradermolingual (IDL) with 10.000 ID50 (infective dose fifty) sheep adapted challenge FMD (O & A types) virus and subjected to clinical observation for 8 days. The results showed that the vaccinated animal with a full, ½, ¼ dose injected either S/C or I/M were able to withstand the virus infection while animals vaccinated with 1/8 dose didn’t
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