Intermittent Calorie Restriction Ameliorates Behavioral Changes and Tau Hyperphosphorylation in Chronic Immobilization Stress in Rats. | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 9, Volume 40, Issue 2, June 2020, Pages 113-125 PDF (582.28 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2020.23788.1045 | ||
| Authors | ||
| Dalia Fathy El Agamy* 1; Fatma El Desouky Ahmed2; Safa Riyad Elfiky2 | ||
| 1Physiology Department, Faculty of Medicine, Menoufia University, Egypt | ||
| 2Clinical Pharmacology Department, Faculty of Medicine, Menoufia University, Egypt | ||
| Abstract | ||
| Background: Chronic stress has been linked to mood and anxiety disorders and alteration of cognitive functions, such as memory. Intermittent calorie restriction (ICR) is a repeated mild stress that enhances the cell ability to combat more severe stress. Aim: Examination of the effects of ICR on rat behaviour and Tau hyperphosphorylation in chronic immobilization stress (CIS) rat model. Methods: 32 rats were divided into 4 equal groups: control, ICR (subjected to ICR protocol), CIS (subjected to CIS protocol), and CIS+ICR (subjected to both CIS and ICR protocols). After performing behavioural (open field and Barnes maze) tests, serum level of corticosterone, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined, and hippocampal tissue level of phosphorylated Tau (phospho-Tau), noradrenaline, and serotonin were measured. Results: We found that, ICR significantly altered the stress-induced anxiety-like behavior and memory disturbances (P<0.001). Rats exposed to both ICR and CIS protocols had significantly lower levels of phospho-Tau, corticosterone, and TNF-α, and enhanced levels of noradrenaline and serotonin than those subjected to CIS alone (P<0.01). Conclusion: our results suggest that ICR protects against chronic stress-induced anxiety-like behaviour, memory disturbance and Tau hyperphosphorylation, possibly through inhibition of hypothalamic pituitary adrenal (HPA) axis, anti-inflammatory effects, and enhancement of noradrenaline and serotonin hormones. | ||
| Keywords | ||
| calorie restriction; locomotor activity; stress; tau proteins | ||
|
Statistics Article View: 290 PDF Download: 266 |
||
